Research in our laboratory focuses on the role of cell signaling in hematopoietic development and disorders. Specifically, the Notch signaling pathway regulates fetal hematopoietic stem cells’ development and cell fate decisions (HSC) in mouse models. The overall goal is to understand the molecular and signaling cues that allow for the vast regeneration potential of fetal HSCs and to develop biomedical and bioengineered approaches that will allow adult bone-marrow HSCs to self-renew and expand with the same potency as fetal HSCs.To accomplish these goals, we rely on transgenic mouse models and embryonic dissection of fetal and adult hematopoietic organs. We use these strategies to accurately detect the hematopoietic development in the mammalian system.